Deary and colleagues examined whether verbal intelligence is associated with persisting to take medication for up to two years. The design was a prospective follow-up of compliance with taking medication in high-risk individuals participating in a randomized, placebo-controlled trial set in Central Scotland. Participants were 1993 people aged between 50 and 77 years with an ankle brachial index = 0.95. The medication was 100 mg aspirin or placebo taken daily. The principal outcome measure was continuing adherence to taking medication or stopping it due to having 'changed one's mind'. Higher verbal intelligence was associated with a greater likelihood of continuing to take medication up to two years after randomization. For a standard deviation increase in Mill Hill Vocabulary Scale score, risk of stopping medication in the first two years of the study was 0.75 (p < 0.001). Comparing the highest and lowest quartiles of IQ, the lowest IQ group's relative rate of stopping medication was 2.51 (95% CI 1.52 to 4.22). The effect was not attenuated after adjustment for sex, smoking, or level of deprivation. Verbal intelligence is associated with continuing, medium-to-long term engagement with health self-care, even in the face of uncertainty about whether active treatment is being received, whether the treatment is known to be effective in general, and whether it will be helpful to the individual taking it.
WHAT THE STUDY MAY MEAN TO YOU AS A HEALTH CARE PROVIDER: The authors concluded that persistence with potentially helpful health behaviors in the face of uncertainty might partly explain why people with higher intelligence live longer and suffer less morbidity from chronic diseases.
WHAT THE STUDY MAY MEAN TO YOU AS A PATIENT: The conclusions reached by the authors are likely true, but they also present a challenge to anyone designing self-management programs for patients at all levels of intelligence. They show that a program must be designed for individual patients if it is to be effective. This can include general reading materials appropriate for all levels of reading capability with extra components tailored for individual patients.
IJ Deary et al. Intelligence and persisting with medication for two years: Analysis in a randomized controlled trial. Intelligence, 2009;37(6):607-612.
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